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Effect of combinatorial therapies on blood plasma parameters. Blood plasma from female ( A , C , E ) and male ( B , D , F ) mice was analyzed for AST activity ( A , B ), creatinine concentrations ( C , D ), <t>and</t> <t>C-peptide</t> levels ( E , F ) following treatment with the BI-3406 (BI) and trametinib (T) combination therapy with or without BKM120 (BKM). Shaded areas indicate the range observed in healthy C57BL/6 mice (n = 5). Statistical analyses were performed using an unpaired t-test ( C – E ) or Mann–Whitney test ( A , B , F ). *p < 0.05
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Effect of combinatorial therapies on blood plasma parameters. Blood plasma from female ( A , C , E ) and male ( B , D , F ) mice was analyzed for AST activity ( A , B ), creatinine concentrations ( C , D ), <t>and</t> <t>C-peptide</t> levels ( E , F ) following treatment with the BI-3406 (BI) and trametinib (T) combination therapy with or without BKM120 (BKM). Shaded areas indicate the range observed in healthy C57BL/6 mice (n = 5). Statistical analyses were performed using an unpaired t-test ( C – E ) or Mann–Whitney test ( A , B , F ). *p < 0.05
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(A-B) H&E staining of primary TC tissue and corresponding 3DP organoids.Scale bars: 50 μm (C) Immunofluorescence images of TC organoids stained for DAPI, CD56, <t>CD117,</t> and pan-CK. Scale bars: 50 μm (D-E) H&E staining of primary THYM tissue and corresponding 3DP organoids. Scale bars: 50 μm (F) Immunofluorescence images of THYM organoids stained for DAPI, P63, pan-CK, and TdT.Scale bars: 100 μm. (G) CNV profiles of TC-Tumor. (H)TC-3DP organoids (I) TC-Matrigel organoids. (J) CNV profiles of THYM-Tumor. (K) THYM-3DP organoids. (L)THYM-Matrigel organoids.
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Image Search Results


Effect of combinatorial therapies on blood plasma parameters. Blood plasma from female ( A , C , E ) and male ( B , D , F ) mice was analyzed for AST activity ( A , B ), creatinine concentrations ( C , D ), and C-peptide levels ( E , F ) following treatment with the BI-3406 (BI) and trametinib (T) combination therapy with or without BKM120 (BKM). Shaded areas indicate the range observed in healthy C57BL/6 mice (n = 5). Statistical analyses were performed using an unpaired t-test ( C – E ) or Mann–Whitney test ( A , B , F ). *p < 0.05

Journal: BMC Cancer

Article Title: Benefits and challenges of adding BKM120 to a BI-3406 plus trametinib combination therapy

doi: 10.1186/s12885-026-16409-0

Figure Lengend Snippet: Effect of combinatorial therapies on blood plasma parameters. Blood plasma from female ( A , C , E ) and male ( B , D , F ) mice was analyzed for AST activity ( A , B ), creatinine concentrations ( C , D ), and C-peptide levels ( E , F ) following treatment with the BI-3406 (BI) and trametinib (T) combination therapy with or without BKM120 (BKM). Shaded areas indicate the range observed in healthy C57BL/6 mice (n = 5). Statistical analyses were performed using an unpaired t-test ( C – E ) or Mann–Whitney test ( A , B , F ). *p < 0.05

Article Snippet: Blood chemistry parameters, such as aspartate aminotransferase (AST), and creatinine were measured using a cobas c111 system (Roche Diagnostics, Mannheim, Germany), and C-peptide levels were quantified with a mouse C-peptide ELISA kit (ALPCO, Salem, USA) according to the manufacturer’s instructions.

Techniques: Clinical Proteomics, Activity Assay, MANN-WHITNEY

(A-B) H&E staining of primary TC tissue and corresponding 3DP organoids.Scale bars: 50 μm (C) Immunofluorescence images of TC organoids stained for DAPI, CD56, CD117, and pan-CK. Scale bars: 50 μm (D-E) H&E staining of primary THYM tissue and corresponding 3DP organoids. Scale bars: 50 μm (F) Immunofluorescence images of THYM organoids stained for DAPI, P63, pan-CK, and TdT.Scale bars: 100 μm. (G) CNV profiles of TC-Tumor. (H)TC-3DP organoids (I) TC-Matrigel organoids. (J) CNV profiles of THYM-Tumor. (K) THYM-3DP organoids. (L)THYM-Matrigel organoids.

Journal: Materials Today Bio

Article Title: Biomimetic 3D-Bioprinted organoids of thymic epithelial tumors for translational drug screening and biomarker identification

doi: 10.1016/j.mtbio.2026.102878

Figure Lengend Snippet: (A-B) H&E staining of primary TC tissue and corresponding 3DP organoids.Scale bars: 50 μm (C) Immunofluorescence images of TC organoids stained for DAPI, CD56, CD117, and pan-CK. Scale bars: 50 μm (D-E) H&E staining of primary THYM tissue and corresponding 3DP organoids. Scale bars: 50 μm (F) Immunofluorescence images of THYM organoids stained for DAPI, P63, pan-CK, and TdT.Scale bars: 100 μm. (G) CNV profiles of TC-Tumor. (H)TC-3DP organoids (I) TC-Matrigel organoids. (J) CNV profiles of THYM-Tumor. (K) THYM-3DP organoids. (L)THYM-Matrigel organoids.

Article Snippet: The following primary antibodies were used: Pan-CK (# MA513203 , invitrogen) at a dilution of 1:100, CD117 (AF1356-SP, R&D system) at a dilution of 1:100, CD56/NACM1 (#ab313779, abcam) at a dilution of 1:100, p63 (#ab124762, abcam) at a dilution of 1:100, TdT (#TB4932S, abmart) at a dilution of 1:100, and Anti-gamma H2A.X (phospho S139) antibody (#ab2893, abcam) at a dilution of 1:100.

Techniques: Staining, Immunofluorescence